Comman Enzyme Mechanism
Type of Catalysis |
Mechanism |
Amino Acids/Actions Commonly Involved |
Approximation |
Holds reactants in correct orientation for reaction to occur |
Charge density, polarity, solvation, active site configuration |
Acid/Base |
Lowers transition state energy of substrate or intermediate by proton addition or removal |
Asp, Glu, His, Lys, Tyr, Arg, Cys, metal ions |
Nucleophilicity |
Donates electrons for enzyme-substrate intermediate formation |
Asp, Ser, Cys, His, Glu |
Electrophilicity |
Withdraws electrons for enzyme-substrate intermediate formation |
Lys, Arg, His; thiamine pyrophosphate, pyridoxal phospate, metal ions |
Distortion or torsional strain |
Binding forces lower enzyme-substrate intermediate transition state energy |
Charge density, polarity, and solvation of active site; active site configuration and flexibility |