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Classification and Nomenclature of Enzymes 

  1. Oxidoreductases

1.1  Acting on the CH-OH group of donors

1.1.1        With NAD or NADP as acceptor

1.1.2        With a cytochrome as an acceptor

1.1.3        With O2 as acceptor

1.1.4        With other acceptors

1.2  Acting on the aldehyde or keto-group of donors

1.2.1        With NAD or NADP as acceptor

1.2.2        With a cytochrome as an acceptor

1.2.3        With O2 as acceptor

1.2.4        With other acceptors

1.3  Acting on the CH-CH group of donors

1.3.1        With NAD or NADP as acceptor

1.3.2        With a cytochrome as an acceptor

1.3.3        With O2 as acceptor

1.3.4        With other acceptors

1.4  Acting on the CH-NH2 group of donors

1.4.1        With NAD or NADP as acceptor

1.4.2        With O2 as acceptor

1.5  Acting on the C-NH group of donors

1.5.1        With NAD or NADP as acceptor

1.5.2        With O2 as acceptor

1.6  Acting on reduced NAD or NADP as donors

1.6.1        With NAD or NADP as acceptor

1.6.2        With a cytochrome as an acceptor

1.6.3        With a disulfide compound as acceptor

1.6.4        With a quinone or related compound as acceptor

1.6.5        With other acceptors

1.7  Acting on other nitrogenous compound as donors

1.7.1        With O2 as acceptor

1.7.2        With  other acceptors

1.8  Acting on sulfur groups of donors

1.8.1        With NAD or NADP as acceptor

1.8.2        With O2 as acceptor

1.8.3        With a disulfide compound as acceptor

1.8.4        With a quinone or related compound as acceptor

1.8.5        With  nitrogenous group as acceptor

1.9  Acting on heme groups of donors

1.9.1        With O2 as acceptor

1.9.2        With  nitrogenous group as acceptor

 1.10 Acting on diphenols and related substances as donors

            1.10.1  With O2 as acceptor

 1.11 Acting on H2O2 as acceptor

 1.12 Acting on hydrogen as donor

          1.13 Acting on single donors with incorporation of oxygen (oxygenases)

          1.14 Acting on paired donors with incorparation of  oxygen into one 

  1. Transferases

    2.1 Transferring one-carbon groups

      2.1.1   Methyltransferases

      2.1.2   Hydroxymethyl-,formyl-,and related transferases

      2.1.3   Carboxyl-and carbamoyltranferases

      2.1.4   Amidinotransferases

    2.2 Transferring aldehydic or ketonic residues

    2.3 Acyltransferases

      2.3.1   Acyltransferases

      2.3.2   Aminoacyltransferases

    2.4 Glycosytransferases

      2.4.1   Hexosyltrannsferases

      2.4.2   Pentosyltransferases

    2.5 Transferring nitrogenous groups

    2.6 Transferring alkyl or related groups

      2.6.1   Aminotransferases

      2.6.2   Oximinotransferases

   2.7 Transferring phosphorus-containing groups

      2.7.1   Phosphotransferases with an alcohol group as acceptor

      2.7.2   Phosphotransferases with a carboxyl group as acceptor

      2.7.3   Phosphotransferases with a nitrogenous group as acceptor

      2.7.4   Phosphotransferases with a phospho-group as acceptor

      2.7.5   Phosphotransferases,apperantly intramolecular

      2.7.6   Phosphotransferases

      2.7.7   Nucleotidyltransferases

      2.7.8   Transferases for other substituted phospho-groups

   2.8 Transferring sulfur-containing groups

      2.8.1   Sulfurtransferases

      2.8.2   Sulfotransferases

      2.8.3   CoA-transferases

3.  Hydrolases

   3.1 Acting on ester bonds

      3.1.1   Carboxylic ester hydrolases

      3.1.2   Thiolester hydrolases

      3.1.3   Phosphoric monoester hydrolases

      3.1.4   Phosphoric diester hydrolases

      3.1.5   Triphosphoric monoester hydrolases

      3.1.6   Sulfuric ester hydrolases

   3.2 Acting on glycosyl compounds

      3.2.1   Glycoside hydrolases

      3.2.2   Hydrolyzing N-glycosyl compounds

      3.2.3   Hydrolyzing S-glycosyl compounds

   3.3 Acting on ether bonds

      3.3.1   Thioether hydrolases

   3.4 Acting on peptide bonds (peptide hydrolases)

      3.4.1   α-Amino-acyl-peptide hydrolases

      3.4.2   Peptidyl-amino-acid hydrolases

      3.4.3   Dipeptide hydrolases

      3.4.4   Ppetidyl-peptide hydrolases

 

   3.5 Acting on C-N bonds other than peptide bonds

     3.5.1   In linear amides

     3.5.2   In cyclic amides

     3.5.3   In linear amidines

     3.5.4   In cyclic amidines

     3.5.5   In cyanides

     3.5.99 In other compounds

   3.6 Acting on acid-anhydride bonds

     3.6.1   In phosphoryl-containing anhydrides

   3.7 Acting on C-C bonds

     3.7.1   In ketonic substances

   3.8 Acting on halide bonds

     3.8.1   In C-halide compounds

     3.8.2   In P-halide compounds

   3.9 Acting on P-N bonds

4.  Lyases

  4.1 Carbon-carbon lyases

     4.1.1   Carboxy-lyases

     4.1.2   Aldehyde-lyases

     4.1.3   Ketoacid-lyases

  4.2 Carbon-oxygen lyases

     4.2.1   Hydro-lyases

     4.2.99  Other carbon-oxygen lyases

  4.3 Carbon-nitrogen lyases

     4.3.1   Ammonia-lyases

     4.3.2   Amidine-lyases

  4.4 Carbon-sulfur lyases

  4.5 Carbon-halide lyases

  4.99 Other lyases

5.  Isomerases

  5.1 Racemases and epimerases

     5.1.1   Acting on amino acids and derivatives

     5.1.2   Acting on hydroxyacids and derivatives

     5.1.3   Acting on carbohydrates and derivatives

     5.1.99 Acting on other compounds

  5.2 Cis-trans isomerases

  5.3 Intramolecular oxidoreductases

     5.3.1   Interconverting aldoses and ketoses

     5.3.2   Interconverting keto-and enol-groups

     5.3.3   Transferring other groups

  5.4 Intramolecular transferases

     5.4.1   Transferring acyl groups

     5.4.2   Transferring phosphoryl groups

     5.4.99 Transferring other groups

  5.5 Intramolecular lyases

  5.99 Other isomerases

6.  Ligases

  6.1 Forming C-O bonds

     6.1.1   Amino-acid-RNA ligases

  6.2 Forming C-S bonds

     6.2.1   Acid-thiol ligases

  6.3 Forming C-N bonds

     6.3.1   Acid-ammonia ligases (amide synthetases)

     6.3.2   Acid-amino-acid ligases (peptide synthetases)

     6.3.3   Cyclo-ligases

     6.3.4   Other C-N ligases

     6.3.5   C-N ligases with glutamine as N-donor

  6.4 Forming C-C bonds